New mRNA pill bypasses injections for gut-targeted therapy (phys.org)
from Domino@quokk.au to science@mander.xyz on 28 Jul 20:40
https://quokk.au/post/148871

#science

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HubertManne@piefed.social on 28 Jul 21:27 collapse

RNACap uses pH-sensitive coatings and pressure-triggered release membranes to remain intact in the stomach. Contents are released in the intestine in response to neutral pH and peristalsis.

Nanoparticles were formulated using G0-C14, PLGA, and PEG-lipid components for mucus penetration and endosomal escape. A 5% DMPE-PEG formulation showed optimal transfection in vitro.

oh man. as a needlephobe. please. please. please.

pressedhams@lemmy.blahaj.zone on 28 Jul 21:34 next collapse

I just saw a similar article about using this delivery method for insulin. I’m just some plebeian but it’s all very interesting!

tenchiken@lemmy.dbzer0.com on 29 Jul 03:04 collapse

Thanks for the summary!

HubertManne@piefed.social on 29 Jul 03:11 collapse

no prob. If I read the article I usually try to paste what I feel is the most relevant bit and once in awhile I will do the whole thing or if its too long I will add a comment encouraging people to read the article if its good enough.