BodyBySisyphus@hexbear.net
on 24 Jul 21:26
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Results indicated that the mice that received an initial low dose of psilocybin of 5 mg/kg, followed by a monthly high dose of 15 mg/kg for 10 months, had a 30% increase in survival compared to mice who hadn’t received any.
So if we take a standard 80 kg adult male, 80 * 15 mg = 1.2 g, which sources indicate is enough for a standard trip. That’s also like almost half an ounce of dried mushrooms. Time to start tripping… for science.
HootinNHollerin@lemmy.dbzer0.com
on 25 Jul 02:05
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1 oz is 28.35 g
BodyBySisyphus@hexbear.net
on 25 Jul 02:30
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Yeah, the paper is talking about pure Psilocybin. I double checked and the rule of thumb is around 1% psilocybin by dry weight so I was actually off and you’d need closer to three ounces.
Forgive me for doubting any studies that don’t involve blinded trials… but this is just one study. Let’s see if it can be replicated before we get excited
ogmios@sh.itjust.works
on 24 Jul 23:10
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Well, I know I’ve done mushrooms a few times, and as of a CT scan at the age of 27, apparently my brain isn’t showing the ordinary signs of aging. Wonder if it’s related.
BurgerBaron@piefed.social
on 25 Jul 01:07
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You'd have to microdose regularly for it to matter if it actually does anything in humans for our telomeres.
A newly published study in Nature Partner Journals’ Aging demonstrates that psilocin, a byproduct of consuming psilocybin, the active ingredient in psychedelic mushrooms,
Maybe my memory is wrong, but I had it the other way around: Psilocin is the active substance, but its not very stable. Psilocybin gets metabolized to Psilocin. Calling it a “byproduct” is kind of underselling it. Psilocybin itself isn’t active by itself.
Quick wiki check confirms this. I always have troubles with articles opening with. I can’t even read that as unfortunate wording.
Bronzebeard@lemmy.zip
on 25 Jul 13:04
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Nuh uh. I’ve seen the Last of US. We all know where this ends up
sixtoe@lemmy.blahaj.zone
on 25 Jul 22:11
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threaded - newest
So if we take a standard 80 kg adult male, 80 * 15 mg = 1.2 g, which sources indicate is enough for a standard trip. That’s also like almost half an ounce of dried mushrooms. Time to start tripping… for science.
1 oz is 28.35 g
Yeah, the paper is talking about pure Psilocybin. I double checked and the rule of thumb is around 1% psilocybin by dry weight so I was actually off and you’d need closer to three ounces.
(15 mg psilocybin / 1 kg body weight) * 80 kg body weight = 1200 mg psilocybin
1200 mg psilocybin * (1 g psilocybin / 100 g dried mushrooms) = 12 g dried mushrooms
I think it’s 12 grams dried mushrooms, which is almost half an ounce, like you first said.
Shouldn’t it be 1200 mg / 0.01 = 120 g of dried mushrooms?
Thank you. I was staring at it and knew the units weren’t canceling out. That’s an insane dose though.
Even the “low dose” is the equivalent of almost 2 oz per dose. Those mice got to convene with the mice gods on the reg I’m sure.
Boofing a whole tray of penis envy shrooms… for science
(15 mg psilocybin / 1 kg body weight) * 80 kg body weight = 1200 mg psilocybin
1200 mg psilocybin = 1.2 g psilocybin * (100 g dried mushrooms / 1 g psilocybin) = 120 g dried mushrooms
There we go.
We should live in Shroom world, everybody will be connected by the mycelium, live long and prosper together.
Yes… let the cordyceps eat your brain… become one with the omnifungi… let our will become yours… listen to the mold as it whispers in your mind…
edit: double post
🤷♂️
Okay, sure, why not
Did you drop this? /s
You’re making it sound pretty damn amazing, frankly. Have you looked around lately? 😅😶🌫️
WE ARE THE ONE!
I am the Globglogabgalab
Eh, beats fascism.
There is already fungi that grows in your throat. Humans are connected to the mycelium - the most advanced lifeform on this planet.
Forgive me for doubting any studies that don’t involve blinded trials… but this is just one study. Let’s see if it can be replicated before we get excited
Oh, I am going to try to replicate this study. I’ll hit you back in about 50 years if it worked.
It takes you 50 years to transform into a mouse?
Or sooner, once the medicine kicks in.
Whoa. You’re a mouse now?
Well, I know I’ve done mushrooms a few times, and as of a CT scan at the age of 27, apparently my brain isn’t showing the ordinary signs of aging. Wonder if it’s related.
You'd have to microdose regularly for it to matter if it actually does anything in humans for our telomeres.
Wow you sure seem to know one hell of a lot about the inner workings of this newly discovered phenomena.
Your sarcasm is noted, but seems daft when you suggest you'll live longer because you ate a funny mushroom a couple times.
Not sure where you read any of that in my posts.
Idc, I’ll just die old, no one’s ever gonna get me to willingly take hallucinogens
Go ahead and hit me with the <img alt="downbear" src="https://hexbear.net/api/v3/image_proxy?url=https%3A%2F%2Fchapo.chat%2Fpictrs%2Fimage%2F2ecd0805-fe83-4761-9771-8844f0e83a78.png">, don’t care if that’s an L take or not
You do you. Have fun!
no healthy adult should feel the need to take any drug
Need? Of course not. Desire? Certainly.
Maybe my memory is wrong, but I had it the other way around: Psilocin is the active substance, but its not very stable. Psilocybin gets metabolized to Psilocin. Calling it a “byproduct” is kind of underselling it. Psilocybin itself isn’t active by itself.
Quick wiki check confirms this. I always have troubles with articles opening with. I can’t even read that as unfortunate wording.
Nuh uh. I’ve seen the Last of US. We all know where this ends up
HOLY SHIT IM GONNA LIVE FOREVER
Wake me up when once there are results of a well-designed clinical trial.
My understanding of the article is they’re extrapolating from experiments on mice and on a few human cells in a lab.