Sleeping pills stop the brain’s system for cleaning out waste (arstechnica.com)
from pelespirit@sh.itjust.works to science@mander.xyz on 21 Jan 19:52
https://sh.itjust.works/post/31462941

Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.

#science

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Gullible@sh.itjust.works on 21 Jan 20:20 next collapse

This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid

anarchrist@lemmy.dbzer0.com on 21 Jan 20:31 next collapse

I wonder if ketamine has the same effect, he asked apropos of nothing…

metaStatic@kbin.earth on 21 Jan 20:33 collapse

Anesthesia

yes

MossyFeathers@pawb.social on 21 Jan 21:36 collapse

Actually maybe not? Iirc most “traditional” anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a “blink and you miss it” ordeal, your brain isn’t active enough to be aware that time has passed).

However, if I’m not mistaken, stuff like ketamine or nitrous don’t do that, and sedate you in a manner more similar to natural sleep.

peoplebeproblems@midwest.social on 21 Jan 20:48 next collapse

Fuck.

Now what?

RvTV95XBeo@sh.itjust.works on 22 Jan 02:17 collapse

That usually helps me sleep better too

RobotToaster@mander.xyz on 21 Jan 20:54 next collapse

The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.

__nobodynowhere@lemm.ee on 21 Jan 21:16 collapse

What about Benadryl?

rickyrigatoni@lemm.ee on 21 Jan 22:25 next collapse

The hat man cleans your brain for you.

RobotToaster@mander.xyz on 21 Jan 22:48 collapse

Unknown, but it’s an anticholinergic, and those are associated with dementia.

Cephalotrocity@biglemmowski.win on 21 Jan 21:25 next collapse

Apparently the water supply in my town is dosed with sleeping pills.

pelespirit@sh.itjust.works on 21 Jan 21:31 collapse

Honestly, it might be. When people pee, that toilet water goes somewhere.

Drugs found in Puget Sound salmon from tainted wastewater

workerONE@lemmy.world on 22 Jan 01:21 next collapse

What about alcohol?

Agent641@lemmy.world on 22 Jan 05:02 collapse

Fucks you up

rosa666parks@lemmy.dbzer0.com on 22 Jan 05:15 collapse

Then gets you really sleepy

some_guy@lemmy.sdf.org on 22 Jan 03:38 next collapse

Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.

Hackworth@lemmy.world on 22 Jan 04:37 next collapse

You need healthy, natural sleep. Chew some valerian root and get more exercise.

TacoButtPlug@sh.itjust.works on 22 Jan 04:58 next collapse

I wonder what melatonin does

Agent641@lemmy.world on 22 Jan 05:01 collapse

Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.

TacoButtPlug@sh.itjust.works on 22 Jan 05:23 collapse

Charlie Kelly… who taught you about Lemmy?

DaCrazyJamez@sh.itjust.works on 22 Jan 08:04 collapse

Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain…

flicker@lemmy.dbzer0.com on 22 Jan 05:20 collapse

I have ADHD. Without drugs, I only sleep during the day, and sometimes, I’ll skip a day and feel like crap about it no matter what I do.

I mean without drugs. I used to be an all-natural whackadoo.

Nowadays I do drugs about it and I’m allowed to be a real human. Guess my brain will clean itself when I die.