Sleeping pills stop the brain’s system for cleaning out waste
(arstechnica.com)
from pelespirit@sh.itjust.works to science@mander.xyz on 21 Jan 2025 19:52
https://sh.itjust.works/post/31462941
from pelespirit@sh.itjust.works to science@mander.xyz on 21 Jan 2025 19:52
https://sh.itjust.works/post/31462941
Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.
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This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid
Obviously I understand what femininely turgid means but can you explain it just in case somebody else doesn’t know?
ie: ladyboner, the old slip n slide, juices flowing, mine honeypot overfloweth
Like a lil cashew down there.
I wonder if ketamine has the same effect, he asked apropos of nothing…
yes
Actually maybe not? Iirc most “traditional” anesthesia basically knocks you down to the bare minimum of brain activity to remain alive and reliably regain consciousness (which is why being under anesthesia is usually a “blink and you miss it” ordeal, your brain isn’t active enough to be aware that time has passed).
However, if I’m not mistaken, stuff like ketamine or nitrous don’t do that, and sedate you in a manner more similar to natural sleep.
Fuck.
Now what?
That usually helps me sleep better too
Plenty of things to try.
youtu.be/lIo9FcrljDk?si=OOCPIQO7e9r_Oemw
The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.
What about Benadryl?
The hat man cleans your brain for you.
Unknown, but it’s an anticholinergic, and those are associated with dementia.
Apparently the water supply in my town is dosed with sleeping pills.
Honestly, it might be. When people pee, that toilet water goes somewhere.
Drugs found in Puget Sound salmon from tainted wastewater
What about alcohol?
Fucks you up
Then gets you really sleepy
Being knocked out is not sleep.
Suppresses dreams and dreams are apparently good and needed for a healthy brain.
Se thing as any other substance
Weed too
What about sniffing glue?
That shit don't last long enough?
Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.
I wonder what melatonin does
Forget melatonin, I want to know wtf cheese is doing to my brain when I sleep on it.
Charlie Kelly… who taught you about Lemmy?
Im pretty sure cat food and spray paint shut down m9re than just the NREM cycle in the brain…
Probably just stick to the side of your head.
Have you tried eating the cheese instead?
It’s a natural hormone brain produces that signals to the body that it’s zzz time.
I love it for bedtime and it helps my autoimmune shit. Glad it’s not brain bad.
Aside from possibly becoming a dependency, I’d imagine it doesn’t interfere with sleep quality. It’s what builds up in your body to make you sleepy/fall asleep.
Too much might keep you groggy in the morning though.
I have ADHD. Without drugs, I only sleep during the day, and sometimes, I’ll skip a day and feel like crap about it no matter what I do.
I mean without drugs. I used to be an all-natural whackadoo.
Nowadays I do drugs about it and I’m allowed to be a real human. Guess my brain will clean itself when I die.
Be careful about assuming that your drugs are what they’re talking about. Yours sound like they’re balancing you out. They could be cleaning out your brain. Make sure to look at the study carefully.
you probably just need fresh nutrients
Alcohol and weed does the same thing, just because you are out. Doesn't mean you are sleeping.
Good to see this common sense being confirmed
I wouldn’t even call it common sense. I remember being taught like 20 years ago that we don’t even know for sure why we need to sleep (aside from the fact that we get tired and sleep is pretty good at helping with that).
If you want your brain to clean out waste at night, you need to be taking sweeping pills.