Antidepressant of the masses
from qaz@lemmy.world to science_memes@mander.xyz on 29 Jul 11:58
https://lemmy.world/post/33641442

Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain

#science_memes

threaded - newest

ryedaft@sh.itjust.works on 29 Jul 12:19 next collapse

Does it elicit a psychoactive reaction or does it affect TRPV3 in vitro?

be honest David Beckham meme

protist@mander.xyz on 29 Jul 12:35 next collapse

In vivo in mice

fullsquare@awful.systems on 29 Jul 14:01 collapse

is TRPV3 even involved in any way because last time i’ve checked some of best evidence points in direction of TrkB

ArchmageAzor@lemmy.world on 29 Jul 12:29 next collapse

I got some frankincense and lit it, now my apartment smells like smoke

defaultusername@lemmy.dbzer0.com on 29 Jul 17:14 collapse

Just as John Frankincense intended.

Tolookah@discuss.tchncs.de on 29 Jul 13:10 next collapse

Now someone is going to make a Frankincense vapes

Corkyskog@sh.itjust.works on 29 Jul 22:31 collapse

Extract in a passive nasal inhaler device like Poy-Sian would probably work.

<img alt="" src="https://sh.itjust.works/pictrs/image/86385b83-34ea-4c1d-8a8f-3d437d6795b3.jpeg">

nomy@lemmy.zip on 29 Jul 23:19 collapse

Is that bottle actually labeled “Poy-sian” like poison?

Corkyskog@sh.itjust.works on 30 Jul 00:56 collapse

Its from Thailand… There is a stop between the word and a heavy emphasis on the y.

Phoentically It’s like poY - - see - an

Diplomjodler3@lemmy.world on 29 Jul 13:23 next collapse

Uh yeah, how is that new? That was always the point of using the stuff.

ArchmageAzor@lemmy.world on 29 Jul 14:00 collapse

I figured it was traditionally used because it’s what was given to baby JC by the three wise men, so it’s considered holy in a sense

Diplomjodler3@lemmy.world on 29 Jul 14:32 collapse

It’s a drug and has always been used as such. Why do you think that stuff was so valuable?

Lumisal@lemmy.world on 29 Jul 15:06 next collapse

Smells nice? I mean, that’s basically the value of perfumes too

Evil_Shrubbery@lemmy.zip on 29 Jul 15:06 collapse

Bcs the market speculation predicted that after prob 1k years it will enter the mass use by a major religion & could be sold at a higher price then, duh.

/s

AllNewTypeFace@leminal.space on 29 Jul 14:44 next collapse

That’s what they used to call “Church Air”

SlartyBartFast@sh.itjust.works on 29 Jul 15:02 next collapse

Here and I thought the smoke was meant to keep mosquitos away

Buddahriffic@lemmy.world on 30 Jul 16:51 collapse

Maybe it doesn’t actually keep them away but just gets them too high to be interested in biting.

jaybone@lemmy.zip on 29 Jul 15:15 next collapse

I want to see someone correct that commentor by telling them frankincense was the name of the doctor not the monster.

pruwybn@discuss.tchncs.de on 29 Jul 15:42 next collapse

Frankincense was actually the name of the wise man.

_AutumnMoon_@lemmy.blahaj.zone on 30 Jul 01:18 collapse

Knowledge is knowing Frankincense is the doctor. Wisdom is knowing Frankincense is the monster

Akasazh@feddit.nl on 30 Jul 09:25 collapse

Frankly, that makes no sense

defaultusername@lemmy.dbzer0.com on 29 Jul 17:13 collapse

The monster’s name was Adam Frankincense.

Damage@feddit.it on 29 Jul 16:05 next collapse

So the Church has wine and antidepressants in its rituals…

yuri@pawb.social on 29 Jul 17:51 next collapse

incensole acetate has ~1/10th the anti-anxiety potency of valium, which is pretty darn high if you think about it!

myrrh is also psychoactive, but it’s a straight up opoid agonist. it was commonly used as a pain reliever before the widespread use of opium poppies. in high-ish concentrations folks report general euphorua, dream-like states, and even vivid/lucid dreams! i can personally attest to the first two hahah

ChickenLadyLovesLife@lemmy.world on 29 Jul 23:37 collapse

Next you’re gonna tell me gold is psychoactive!

grissino@lemmy.world on 30 Jul 10:06 collapse

Having lots of it would indeed make me happier :p

TankovayaDiviziya@lemmy.world on 29 Jul 18:22 next collapse

Religion itself is said to be natural antidepressant. I do wonder if exposure by our ancestors to psychoactive substances is tied to the development of religion.

captain_aggravated@sh.itjust.works on 29 Jul 23:38 collapse

Hell just the chords they play on the organ. You could probably write a song about licking envelopes in the style of a church hymn and get people to worship the Postmaster General.

WoodScientist@sh.itjust.works on 30 Jul 01:41 collapse

I mean, I have been looking for a cult to join, if you were looking to start one.

captain_aggravated@sh.itjust.works on 30 Jul 02:07 collapse

Well join us at !woodworking@lemmy.ca. We could use a wood scientist.

Drusas@fedia.io on 29 Jul 21:54 next collapse

So, uh, how would one make use of this knowledge?

Corkyskog@sh.itjust.works on 29 Jul 22:23 collapse

Probably shouldn’t experiment with large doses of barely understood substances… But if someone really wanted to.

You can buy Incensole Acetate from chemical companies, but it’s like hundred dollars for a few milligrams. Would have been cool for it to be cheap this form because you could probably use it in a passive nasal inhaler device at that strength.

However you can buy 4oz of frankincense resin for ~$30. I would imagine that will have much more of Incensole than a few mg. No idea if it would be easy to inhale in vapor form or if you would have to burn it.

No idea how reputable these sites selling it are, but here is one.

captain_aggravated@sh.itjust.works on 29 Jul 23:36 collapse

How have we allowed a substance used by a major religion for two millennia remain a “barely understood substance?”

Corkyskog@sh.itjust.works on 30 Jul 00:53 collapse

Yeah, but they weren’t inhaling an isolate. It’s all about the dose.

Edit: I misread your comment. I don’t know why there isn’t more research into the pathways frankincense uses to generate its effects. Probably because it’s rarely been used in a directly applied medical way instead of a communal or ceremonial use.

Asidonhopo@lemmy.world on 29 Jul 22:29 next collapse

Somewhere, Dr. Ammon Hillman has read this and is grinning maniacally.

WoodScientist@sh.itjust.works on 30 Jul 01:38 collapse

I was going to go with Marx. Turns out religion is the LITERAL opiate of the masses!

Asidonhopo@lemmy.world on 30 Jul 04:17 collapse

Makes sense with Marx too I guess but Hillman, who has a doctorate in classics and a masters (I think) in one of the biosciences has been pushing for more awareness of the countless references to recreational and sacramental drug use in antiquity for over a decade now. He’s not for everybody but he’s read ancient Greek for over 3 decades and finds some pretty surprising accounts of it in neglected medical and other texts he continues to translate.

SkyHeart@lemmy.zip on 29 Jul 23:02 next collapse

I actually got my hands on Frankincense drops and started to eat them like crazy, when I decided to try one of them. It tasted like actual raw glass like rocks although I liked eating them and didn’t knew why until now. Although they have almost zero to non taste eating them was quite addictive in my experience

vaultdweller013@sh.itjust.works on 29 Jul 23:29 collapse

I’ll stick with my family trait that means when we fight we get happy brain juice, I just wish boxing or MMA could trigger it but it doesn’t. If the fight can’t theoretically end with me getting gutted with a rusty knife I want nothing to do with it, I want to Cain someone’s Able.

qaz@lemmy.world on 30 Jul 07:12 collapse

Okay? Stay safe, I guess