genotype rarity: ⭐⭐⭐⭐⭐
from match@pawb.social to science_memes@mander.xyz on 15 Mar 00:06
https://pawb.social/post/21396568

“A Novel Sex Chromosome Mosaicism 45,X/45,Y/46,XY/46,YY/47,XYY Causing Ambiguous Genitalia”

#science_memes

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Bishma@discuss.tchncs.de on 15 Mar 02:00 next collapse

Ambiguous Genitalia would make a good pub quiz team name.

200ok@lemmy.world on 15 Mar 02:38 collapse

The Novel Sex Chromosomes was the name of my college marching band

blackbrook@mander.xyz on 15 Mar 05:21 collapse

45,X/46,XX, 45,X/46,XY and 46,XY/47,XXY was my locker combination in high school!

muhyb@programming.dev on 15 Mar 06:36 next collapse

Is YY possible though? Never heard of that one.

schibutzu@lemm.ee on 15 Mar 07:00 next collapse

I think it’s not, since the X chromosome contains vital genes while the Y chromosome kinda does nothing. If you don’t have an X chromosome, you should be missing important genes. I might be wrong though.

muhyb@programming.dev on 15 Mar 07:05 collapse

I heard about XYY, XXY and even XXX so was wondering about this one. Since it’s still 50/50 (more or less) and it has to contain at least one X, I would guess. Still confused by the article title though.

match@pawb.social on 15 Mar 07:53 collapse

YY is not possible in isolation because you need at least an X chromosome to survive as stated above, however! this article is about someone with extreme mosaicism, meaning that some of his cells don’t have the same chromosomes as the rest of his body, so some of his cells are YY but other parts of his body have X chromosomes so it’s still survivable overall

muhyb@programming.dev on 15 Mar 08:43 collapse

Wow, so kinda like chimerism? Though this is on another level. Couldn’t find a wiki page but definitely would like to read about it. By the way, while searching for this, I found about XXYY which I also didn’t know about.

Ledericas@lemm.ee on 15 Mar 10:09 collapse

Monotremes possess 5X and Ys, but their system is more related to birds and reptiles ZW,

Rudee@lemmy.ml on 15 Mar 08:04 next collapse

Normally no, since one gonosome comes from each parent: The mother (XX) and the father (XY).

If somehow a series of unfortunate meioses occurred to create a zygote that had two Y chromosomes and no X chromosome, the foetus would absolutely not be viable, since the X chromosome contains many essential genes, while the Y chromosome is a truncated version that has less than half the information

Ledericas@lemm.ee on 15 Mar 10:16 collapse

There are situations that occur during fertilization, if the egg somehow loses it genetic material, the sperm enters the egg, but it duplicates its own half genome to form a 46 pairs but this is abnormal, because the gene pattering and also epigenetic silencing is different from males and females, so it forms abnormal mass of tissue called a mole; it can be partial or complete, one of the types can become a rare form of cancer

Rudee@lemmy.ml on 15 Mar 15:05 collapse

TIL meiosis gone wrong can cause a cumshot to give you cancer.

Thanks, internet stranger!

Ledericas@lemm.ee on 15 Mar 23:49 collapse

theres one that have the normal egg with its half of genetic material, but situation where 2 sperm enters at once.

undefinedValue@programming.dev on 15 Mar 16:07 next collapse

You can be XYY and doctors will shorten that informally to YY. www.webmd.com/…/what-are-yy-chromosomes

muhyb@programming.dev on 15 Mar 18:36 collapse

I see. That makes sense.

FundMECFSResearch@lemmy.blahaj.zone on 15 Mar 18:50 collapse

If YY happens, the fetus will not form normally and you will probably have at best a miscarriage

match@pawb.social on 15 Mar 07:48 next collapse

nobody called me on this actually being karyotypes and not genotypes. I’m disappointed

flora_explora@beehaw.org on 15 Mar 09:04 collapse

Interesting how they call this child a “boy” if the karyotype and genitalia are so ambiguous. Like, why???

kuberoot@discuss.tchncs.de on 15 Mar 09:59 collapse

A three years old apparently male child was referred to Anhui Provincial hospital with a complaint of undifferentiated external genitalia.

It might just be that that’s what they’re registered as, or how parents referred to them, I guess?

flora_explora@beehaw.org on 16 Mar 08:03 collapse

Well, the child is three years old and certainly has no concept of gender/sex. So how and why is someone apparently assigning gender and sex to this child? Why not just keep it neutral? Especially in context of forced gender and sex assignations as well as intersex child mutilations. Shouldn’t we be much more careful in this context not to force our biases and weird ideas of gender/sex onto children?!

TonyTonyChopper@mander.xyz on 16 Mar 11:37 next collapse

China is not known for social progressivism

[deleted] on 01 Apr 06:58 collapse

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