So taking this would be all side effects and no benefits
So it’s basically the same as Prozac? 😩
ALoafOfBread@lemmy.ml
on 17 Jun 11:52
nextcollapse
If you have depression anxiety and find that Prozac (an ssri) doesnt work well, you might consider something that directly works on dopamine - like Buproprion (brand name = wellbutrin, a NDRI, norepinephrine dopamine reuptake inhibitor).
SNRIs are also an option, but they can be worse to get off of than heroin.
PoliteDudeInTheMood@lemmy.ca
on 18 Jun 01:49
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I was on Effexor XR Max Dose, and one day when I realized that it had effectively killed all feelings I stopped cold turkey, zero side effects. My doctor thinks I have a very high drug tolerance, to the point that anything I’m put on nowadays is just started at close to the max dose. I’m on a drug right now that is prescribed at a level that would normally result in death for most people, and he thinks I can go higher if I need to.
Downside is pain drugs don’t work, at all. He told me they’d need to give me IV pain meds if I really needed any pain suppression.
CompactFlax@discuss.tchncs.de
on 17 Jun 13:23
nextcollapse
I was a bit of not interested and not educated enough to know what a NDRI was while I was on it but it does make sense for ADHD and Depression symptoms.
The withdrawal from Wellbutrin was bad. I got brain zaps if I was 1hr late taking it; tapering and cessation was miserable.
I have gone off a few times over the years and didn’t experience many side effects/withdrawals, but that is definitely not always the case - I’ve heard that it reeeaaally does not work for some people. Ymmv
Similar to your comment about ADHD, I feel like it helps me with some of my autism symptoms (“low support needs”/aspergers)
y0kai@lemmy.dbzer0.com
on 17 Jun 15:34
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Wellbutrin and lexapro did it for me. Thank god
FiddlersViridian@sh.itjust.works
on 18 Jun 02:39
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This is obviously anecdotal, but fuck Wellbutrin. It didn’t help, and it triggered tinnitus, which didn’t go away after I stopped taking it. Still happening 2 years later. I’m one of the lucky 3-6%
Eeeeeeeeeeeeeeeeeeee
ALoafOfBread@lemmy.ml
on 18 Jun 04:03
nextcollapse
Sorry that happened. I get relatively minor tinnitus, but these exercises have helped. Dude’s a chiropractor, but this particular stuff is not chiropractic and is legit. The thing that helps me is the palms on ears and drumming with fingers on the back of your head (like 50% through the video or so)
FiddlersViridian@sh.itjust.works
on 18 Jun 10:43
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Thank you, I’ll give this a shot! I’ve tried the one you suggested in the past and unfortunately it didn’t help much, but I’ve seen it recommended often enough that I believe it’s legit. Some of the others in this video are new to me and I’ll definitely be trying them out.
It goes up and down (louder and quieter?) for me, and it’s especially strong lately so I’m a little extra salty about it right now. 🫠
TheRealKuni@midwest.social
on 18 Jun 05:09
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I’m sorry you experienced that. Personally I love Wellbutrin.
NeatNit@discuss.tchncs.de
on 17 Jun 12:43
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I realize this isn’t serious but holy shit Prozac might have saved my life. Well, technically Prizma which is the same stuff. I went through so many unsuccessful depression treatments, Prizma is the only one that seems to be sticking. Sometimes the old stuff is just the best.
Worth noting that all treatments were in conjunction with psychotherapy, I don’t think pills alone would have helped. And I also tried going without medication at all for a while, it wasn’t good either. Prizma really is the only thing that works for me.
Edit: apparently the Prizma brand might only be sold in my country, but as I said it’s just a different brand of Prozac.
You say the old stuff but fluoxetine was released in 1986 and citalopram in 1989 - before that you were boned. A few antidepressants existed and they were even worse than what we have today.
JustJack23@slrpnk.net
on 17 Jun 12:30
nextcollapse
Maybe they can offer a two for one deal with lobotomy?
They remove the “problematic” part and install a new, dopamine rich part.
LastYearsIrritant@sopuli.xyz
on 17 Jun 13:03
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MonkeMischief@lemmy.today
on 17 Jun 15:18
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This made me laugh way more than it should have rofl
AbnormalHumanBeing@lemmy.abnormalbeings.space
on 17 Jun 11:43
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I might be misremembering, but AFAIK, dopamine can’t cross the blood-brain-barrier, so even where you want to regulate dopamine (and not, e.g. serotonin like more commonly for depression) in the brain, you have to do so via different medication (e.g. amphetamine derivatives for ADHD or dopamine agonists for Parkinson’s).
The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior.
So it is a neurotransmitter but has many different functions as such. But also:
Outside the central nervous system, dopamine functions primarily as a local paracrine messenger. In blood vessels, it inhibits norepinephrine release and acts as a vasodilator; in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it.
So dopamine is important for all kinds of cells to function correctly. So just chugging a bunch of dopamine would do all kinds of stuff to your body…
Nurse_Robot@lemmy.world
on 17 Jun 11:10
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Gimme
latenightnoir@lemmy.blahaj.zone
on 17 Jun 11:17
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Shove it right up my eyeballs!
The_Che_Banana@beehaw.org
on 17 Jun 12:00
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I want it in my dick hole
…for SCIENCE!
BootLoop@sh.itjust.works
on 17 Jun 11:27
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They found the cure for Sigma
jawa22@lemmy.blahaj.zone
on 17 Jun 11:31
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What’s sigma?
RustyNova@lemmy.world
on 17 Jun 11:35
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Sigma balls
disguy_ovahea@lemmy.world
on 17 Jun 11:38
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Sigma balls 🫳🗯️
miss_demeanour@lemmy.dbzer0.com
on 17 Jun 13:07
nextcollapse
oof
Venus_Ziegenfalle@feddit.org
on 17 Jun 14:12
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Steven Paul Jobs (February 24, 1955 – October 5, 2011) was an American businessman, inventor, and investor best known for co-founding the technology company Apple Inc. Jobs was also the founder of NeXT and chairman and majority shareholder of Pixar. He was a pioneer of the personal computer revolution of the 1970s and 1980s, along with his early business partner and fellow Apple co-founder Steve Wozniak.
Jobs was born in San Francisco in 1955 and adopted shortly afterwards. He attended Reed College in 1972 before withdrawing that same year. In 1974, he traveled through India, seeking enlightenment before later studying Zen Buddhism. He and Wozniak co-founded Apple in 1976 to further develop and sell Wozniak’s Apple I personal computer. Together, the duo gained fame and wealth a year later with production and sale of the Apple II, one of the first highly successful mass-produced microcomputers.
Jobs saw the commercial potential of the Xerox Alto in 1979, which was mouse-driven and had a graphical user interface (GUI). This led to the development of the largely unsuccessful Apple Lisa in 1983, followed by the breakthrough Macintosh in 1984, the first mass-produced computer with a GUI. The Macintosh launched the desktop publishing industry in 1985 (for example, the Aldus Pagemaker) with the addition of the Apple LaserWriter, the first laser printer to feature vector graphics and PostScript.
Edit: i assume the downvotes is because it sounds ai generated or something? It’s copy-paste from wikipedia you numbnuts
I wasn’t going to explain all of the health effects, aside from an irritant, that the “!” could indicate, especially when the general rule of thumb is to go over the SDS when you see the symbol. The second symbol is definitely for indicating a hazard to aquatic life.
The “G” in the third was confused with a “Q”, given the printer resolution. I wasn’t sure, so I used more relative wording for saying what it looked like on my screen.
Coral? I always assumed that was a tree and it means “hazardous to the environment”
hungprocess@lemmy.sdf.org
on 17 Jun 16:12
collapse
I have no idea what that middle warning symbol is trying to convey. Raises undead fish from their graves? Makes you throw fish at your neighbor’s driveway? Will cause flooding across the entire state of Virginia?
threaded - newest
Why don’t they just prescribe this instead of stuff that doesn’t help and also breaks your penis? 😬
Dopamine does a lot of things. It does not cross the blood-brain barrier.
So taking this would be all side effects and no benefits
So it’s basically the same as Prozac? 😩
If you have depression anxiety and find that Prozac (an ssri) doesnt work well, you might consider something that directly works on dopamine - like Buproprion (brand name = wellbutrin, a NDRI, norepinephrine dopamine reuptake inhibitor).
SNRIs are also an option, but they can be worse to get off of than heroin.
I was on Effexor XR Max Dose, and one day when I realized that it had effectively killed all feelings I stopped cold turkey, zero side effects. My doctor thinks I have a very high drug tolerance, to the point that anything I’m put on nowadays is just started at close to the max dose. I’m on a drug right now that is prescribed at a level that would normally result in death for most people, and he thinks I can go higher if I need to.
Downside is pain drugs don’t work, at all. He told me they’d need to give me IV pain meds if I really needed any pain suppression.
I was a bit of not interested and not educated enough to know what a NDRI was while I was on it but it does make sense for ADHD and Depression symptoms.
The withdrawal from Wellbutrin was bad. I got brain zaps if I was 1hr late taking it; tapering and cessation was miserable.
I have gone off a few times over the years and didn’t experience many side effects/withdrawals, but that is definitely not always the case - I’ve heard that it reeeaaally does not work for some people. Ymmv
Similar to your comment about ADHD, I feel like it helps me with some of my autism symptoms (“low support needs”/aspergers)
Wellbutrin and lexapro did it for me. Thank god
This is obviously anecdotal, but fuck Wellbutrin. It didn’t help, and it triggered tinnitus, which didn’t go away after I stopped taking it. Still happening 2 years later. I’m one of the lucky 3-6% Eeeeeeeeeeeeeeeeeeee
Sorry that happened. I get relatively minor tinnitus, but these exercises have helped. Dude’s a chiropractor, but this particular stuff is not chiropractic and is legit. The thing that helps me is the palms on ears and drumming with fingers on the back of your head (like 50% through the video or so)
Thank you, I’ll give this a shot! I’ve tried the one you suggested in the past and unfortunately it didn’t help much, but I’ve seen it recommended often enough that I believe it’s legit. Some of the others in this video are new to me and I’ll definitely be trying them out.
It goes up and down (louder and quieter?) for me, and it’s especially strong lately so I’m a little extra salty about it right now. 🫠
I’m sorry you experienced that. Personally I love Wellbutrin.
I realize this isn’t serious but holy shit Prozac might have saved my life. Well, technically Prizma which is the same stuff. I went through so many unsuccessful depression treatments, Prizma is the only one that seems to be sticking. Sometimes the old stuff is just the best.
Worth noting that all treatments were in conjunction with psychotherapy, I don’t think pills alone would have helped. And I also tried going without medication at all for a while, it wasn’t good either. Prizma really is the only thing that works for me.
Edit: apparently the Prizma brand might only be sold in my country, but as I said it’s just a different brand of Prozac.
You say the old stuff but fluoxetine was released in 1986 and citalopram in 1989 - before that you were boned. A few antidepressants existed and they were even worse than what we have today.
Maybe they can offer a two for one deal with lobotomy?
They remove the “problematic” part and install a new, dopamine rich part.
Just inject it straight into your brain
I’m going to try it.
Edit: smmmfrrrr grreendch ferrrmenspolendllllllllll
This made me laugh way more than it should have rofl
I might be misremembering, but AFAIK, dopamine can’t cross the blood-brain-barrier, so even where you want to regulate dopamine (and not, e.g. serotonin like more commonly for depression) in the brain, you have to do so via different medication (e.g. amphetamine derivatives for ADHD or dopamine agonists for Parkinson’s).
Just inject it directly into the brain smh
From Wikipedia on dopamine:
So it is a neurotransmitter but has many different functions as such. But also:
So dopamine is important for all kinds of cells to function correctly. So just chugging a bunch of dopamine would do all kinds of stuff to your body…
Gimme
Shove it right up my eyeballs!
I want it in my dick hole
…for SCIENCE!
They found the cure for Sigma
What’s sigma?
Sigma balls
Sigma balls 🫳🗯️
oof
Boom got’em
Who’s Steve Jobs?
Steven Paul Jobs (February 24, 1955 – October 5, 2011) was an American businessman, inventor, and investor best known for co-founding the technology company Apple Inc. Jobs was also the founder of NeXT and chairman and majority shareholder of Pixar. He was a pioneer of the personal computer revolution of the 1970s and 1980s, along with his early business partner and fellow Apple co-founder Steve Wozniak.
Jobs was born in San Francisco in 1955 and adopted shortly afterwards. He attended Reed College in 1972 before withdrawing that same year. In 1974, he traveled through India, seeking enlightenment before later studying Zen Buddhism. He and Wozniak co-founded Apple in 1976 to further develop and sell Wozniak’s Apple I personal computer. Together, the duo gained fame and wealth a year later with production and sale of the Apple II, one of the first highly successful mass-produced microcomputers.
Jobs saw the commercial potential of the Xerox Alto in 1979, which was mouse-driven and had a graphical user interface (GUI). This led to the development of the largely unsuccessful Apple Lisa in 1983, followed by the breakthrough Macintosh in 1984, the first mass-produced computer with a GUI. The Macintosh launched the desktop publishing industry in 1985 (for example, the Aldus Pagemaker) with the addition of the Apple LaserWriter, the first laser printer to feature vector graphics and PostScript.
Edit: i assume the downvotes is because it sounds ai generated or something? It’s copy-paste from wikipedia you numbnuts
I think he was asking about the homeless dude from Austin with the ironic last name from the 1940s.
how did he not know who Steve Jobs was?
<img alt="" src="https://lemmy.world/pictrs/image/824d8baf-ec2a-405f-a965-e71db1bda4c2.webp">
There has always been a cure but people aren’t all sure about ligma.
I can’t believe they called the design program Figma.
I use this often at work and it’s always good for a joke or two.
I worry with all the antivaxxers that Demeaning Plebney will make a return.
<img alt="" src="https://lemmy.ca/pictrs/image/fbcce0b9-d151-4e98-ab55-f6f858259b9f.jpeg">
Overpriced dophamine
considering it is made by sigma aldrich, atleast a 10x markup plus your first born child
sigma balls
Damn you beat me to it
What's ligma, brother?
Not what, but who. Ligma is related to Lee Ghandi
Who is Lee Ghandi?
Lee Ghandi’s nuts
❤️
As a non-chemistry person, I assume the red diamonds are to ensure I don’t put this in my mouth?
The first is a standard warning symbol, telling you to read the warnings.
The middle looks to imply that it’s harmful to aquatic life; so no flushing, (upside-down fish and a piece of coral)
Third one seems to be dosage frequency, but saying a symbol isn’t available. (QHS = taken every night)
The third one is “no GHS symbol”, GHS being the Globally Harmonized System of Classification and Labelling of Chemicals.
That makes more sense, I wasn’t sure why they would be talking about dosage on a mfr label
Cool. I learned something. Thanks!
To translate the sibling, the third one is where it would tell you how dangerous the substance is for you. But it’s keeping its secrets.
I think, that’s not a coral, but rather a dead tree next to a stream…
At least make sure the thing you post is correct for something like this, as it can be important.
The first one (exclamation mark) means it is a irritant and the second one means it is hazardous to the environment (not just aquatic)
.
Easy there, tiger. 1/3 incorrect.
I wasn’t going to explain all of the health effects, aside from an irritant, that the “!” could indicate, especially when the general rule of thumb is to go over the SDS when you see the symbol. The second symbol is definitely for indicating a hazard to aquatic life.
The “G” in the third was confused with a “Q”, given the printer resolution. I wasn’t sure, so I used more relative wording for saying what it looked like on my screen.
Source: epa.gov/…/hazard_communication_standard-safety_da…
The exclamation can mean that it’s an irritant. It could also be other potential health concerns.
Try not to be too quick when trying to correct someone next time, especially when you are only half right
Coral? I always assumed that was a tree and it means “hazardous to the environment”
I have no idea what that middle warning symbol is trying to convey. Raises undead fish from their graves? Makes you throw fish at your neighbor’s driveway? Will cause flooding across the entire state of Virginia?
Deadly/dangerous to the environment. It’s supposed to be a dead tree and fish next to a river/water body.
cs.wikipedia.org/…/File%3AGHS-pictogram-pollu.svg