Alright nerds, please explain this one. I’m interested.
ryedaft@sh.itjust.works
on 23 May 18:13
nextcollapse
This is what biochemists have demanding your respect for. “Hello, I would like Mitogen Activated Protein kinase kinase kinase apples”. Statements dreamt up by the utterly deranged.
TonyTonyChopper@mander.xyz
on 23 May 19:43
nextcollapse
This is a map of signaling pathways in a cell. Essentially, how does a cell detect a stimulus and how does the cell respond to it. Signaling networks are notoriously difficult to parse, in major part because many of the proteins that make up the network are promiscuous (meaning that they target many types of proteins instead of just 1). Think of network as less of a series of defined steps and more of a chaotic mess. It’s so chaotic that most maps will select a theme (ie, hormone detection, stress signaling, infection, etc.) and only show the interactions that are relevant to that theme. Unfortunately, that also means that each map will show a network that’s completely different from the others, even though the proteins are the same.
The joke here is that it’s very tempting to make another map. This map is finally going to solve cell biology, I promise, we just have to make another map. Ignore the fact that we already have so many maps, just one more map is all we need
The funniest thing is when nutrition bros go on pubmed. Find something like proteins that regulate myostatin transcription. Then find a protein that regulates that protein. Repeat. And then they have a citations for how insulin, circadian rhythm, any vitamin, any biosynthesis regulates muscle growth. 🧑🍳😘
threaded - newest
Metabolomics isn’t a real field, it’s a trap invented by sadists.
Alright nerds, please explain this one. I’m interested.
This is what biochemists have demanding your respect for. “Hello, I would like Mitogen Activated Protein kinase kinase kinase apples”. Statements dreamt up by the utterly deranged.
This is chemical biology not biochemistry
What’s next, are you going to tell me gravity waves aren’t the same as gravitational waves?
I see your MAP kinase kinase kinase and raise you MAP kinase kinase kinase phosphorylase
This is a map of signaling pathways in a cell. Essentially, how does a cell detect a stimulus and how does the cell respond to it. Signaling networks are notoriously difficult to parse, in major part because many of the proteins that make up the network are promiscuous (meaning that they target many types of proteins instead of just 1). Think of network as less of a series of defined steps and more of a chaotic mess. It’s so chaotic that most maps will select a theme (ie, hormone detection, stress signaling, infection, etc.) and only show the interactions that are relevant to that theme. Unfortunately, that also means that each map will show a network that’s completely different from the others, even though the proteins are the same.
The joke here is that it’s very tempting to make another map. This map is finally going to solve cell biology, I promise, we just have to make another map. Ignore the fact that we already have so many maps, just one more map is all we need
The funniest thing is when nutrition bros go on pubmed. Find something like proteins that regulate myostatin transcription. Then find a protein that regulates that protein. Repeat. And then they have a citations for how insulin, circadian rhythm, any vitamin, any biosynthesis regulates muscle growth. 🧑🍳😘