ASD jab: Chinese scientists reach milestone in revolutionary gene therapy for autism (www.scmp.com)
from L4s@lemmy.world to technology@lemmy.world on 03 Dec 2023 18:00
https://lemmy.world/post/9093925

ASD jab: Chinese scientists reach milestone in revolutionary gene therapy for autism::undefined

#technology

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Pilokyoma@mujico.org on 03 Dec 2023 18:10 next collapse

This be end very bad

A_A@lemmy.world on 03 Dec 2023 19:24 collapse

You mean to say : “This will end very badly”. How do you say it in your native language ?

lemann@lemmy.one on 04 Dec 2023 01:52 next collapse

Mujico sounds spanish to me, using an app though so can’t actually visit that instance to have a look…

A_A@lemmy.world on 04 Dec 2023 03:02 collapse

Hi lemann,
I am reading your answer to my comment and I am wondering if maybe you are trying to answer to someone else’s comment (?).

(thanks to @idiomaddict@lemmy.world …now I get lemann’s meaning)

idiomaddict@lemmy.world on 04 Dec 2023 19:43 collapse

They’re trying to guess what pilo’s native language might be

Pilokyoma@mujico.org on 04 Dec 2023 04:18 collapse

Esto terminara muy mal.

A_A@lemmy.world on 04 Dec 2023 05:59 collapse

in French I would answer : Qui vivra verra.
(roughly meaning : Future will tell )

NOSin@lemmy.world on 03 Dec 2023 18:13 next collapse

Hello Genism my old friend

Do we really need to have the debate about ASD not needing to be “cured”, again ?

Melobol@lemmy.ml on 03 Dec 2023 18:57 next collapse

There shouldn’t be a debate. If it can be cured that’s great. You don’t need it don’t take it - but there are barely functioning people who can’t take care of themselves at all. They do need help.

Tho I honestly don’t think it can be cured.

NOSin@lemmy.world on 04 Dec 2023 07:47 collapse
thegreatgarbo@lemmy.world on 03 Dec 2023 19:45 next collapse

Do you include folks with level 3 non verbal autism with greater epilepsy frequency and self harm in the group that doesn’t need a therapy?

LavaPlanet@lemmy.world on 03 Dec 2023 21:09 next collapse

Imagine a world more inclusive, for them, first, then ask that question. Imagine if the world could be made more comfortable and less traumatic and painful, for them. And there are some who are of that category that do just fine. So do we force them to change too?

BearOfaTime@lemm.ee on 03 Dec 2023 23:23 next collapse

As a neuro-divergent person I have two words: fuck you.

I’d gladly take a shot to make my biochemistry change. It sucks. And my issues are trivial compared to autism.

rambaroo@lemmy.world on 05 Dec 2023 08:27 collapse

Holy shit, for real.

If I could’ve taken a shot to make it go away and lead a healthy emotional life I would’ve done that in a heartbeat. It sucks so much to be around healthy people and know you’ll never be like them. I don’t resent them, in fact I’m happy for them, but holy shit the envy hurts so much.

Tattorack@lemmy.world on 03 Dec 2023 23:30 collapse

I can imagine a world where technology eliminates the need for people to live with life-debilitating disorders.

Yes, let’s imagine a world less traumatic and painful, filled with people who don’t try to halt technological and medical progress because of personal beliefs.

NOSin@lemmy.world on 04 Dec 2023 07:46 collapse

Yes, because we still got things we wouldn’t have without those people. Because some are barely functioning doesn’t mean they don’t function. And they’re so different than most people than they bring entirely different things to humanity.

It is also an obvious slippery slope to Genism and don’t even try to tell me that humanity can control itself and that this won’t be used the wrong way.

Either you know it will, or you’re clueless about the horrors humanity exacts.

Melobol@lemmy.ml on 04 Dec 2023 21:26 collapse

What they bring is suffering. No one ever wishes for a non responsible child. No one wants their child to be the “special one”. No one wants all the hardship it brings. Even the proxy Munchausen prefers to have a functioning level so they don’t have to do the work. No one wants to be tested by a “greater power” (random gene selection) especially not the sick little being that Teoretically Could be cured but there are people like you who like to decide stuff for OTHERS. How much time do you spend at orphanage with special needs? How much contact do you have to sit on the high horse and try to be god? How much time and money do you spend on personally helping the kids? How many diapers did you change to get to this opinion?

Gene thereapy has a right to exist. And with everything else as humans, we will abuse it to the limit. The problem is not the cure but the mindset. And your pretentious preaching won’t bring conversation only suffering. You are not helping.

NOSin@lemmy.world on 04 Dec 2023 22:06 collapse

You recognize humans will abuse it and then say I’m not helping. I was gonna say that you’re missing the point but as I read more and more, I see you just choose to ignore it, great cognitive dissonance here.

Melobol@lemmy.ml on 05 Dec 2023 00:31 collapse

Let me guess you are anti abortion too.

NOSin@lemmy.world on 05 Dec 2023 03:57 collapse

That doesn’t relate in any way and no. Try again to have a point to make.

Melobol@lemmy.ml on 05 Dec 2023 20:39 collapse

It is the exact argument. You are holding up potential cure because it can be used for evil. While preaching that your way is the only way.

NOSin@lemmy.world on 06 Dec 2023 12:53 collapse

“Cure”, so, again, you’re ignoring the point that considering it as something to be cured is the bigoted point of view. I already explained why, stop cherry picking and trying to make me say what I didn’t, you’re just showing how ignorant you are.

Melobol@lemmy.ml on 06 Dec 2023 20:11 collapse

Interestingly you haven’t answered my question. Hiw much actal contact you had with these people you don’t want to help? At leat have you seen them in real life? Because you are doing everything with your demagogue to hurt them.

NOSin@lemmy.world on 06 Dec 2023 22:55 collapse

I am one, so trust me, I’ve been in quite some contact with “those people”. Now stop using big words you barely understand to spread bullshit you don’t get the range of, and stick to talking about things you at least know a things or two about.

Melobol@lemmy.ml on 07 Dec 2023 02:58 collapse

So you are non responsive person who can’t leave the house and soils the bed. Okay.

NOSin@lemmy.world on 07 Dec 2023 03:48 collapse

Still not addressing points being made, still debating like a child. I will block you now, that’s enough time wasted.

reksas@sopuli.xyz on 04 Dec 2023 21:49 collapse

They have right to choose for themselves.

Pyrozo007@lemmy.dbzer0.com on 03 Dec 2023 18:29 next collapse

What the actual fuck

A_A@lemmy.world on 03 Dec 2023 19:18 collapse

Gene therapy … 🥳👍!
Why are you asking ?

Tattorack@lemmy.world on 03 Dec 2023 18:38 next collapse

Article above is paywalled. This seems to be word for word the same but isn’t paywalled (maybe):

fiorreports.com/asd-vaccine-chinese-scientists-re…

Anyway. Quite impressive if true. So far this seems to have an effect on mice. But humans aren’t mice. We shall see if anything comes from this.

LavaPlanet@lemmy.world on 03 Dec 2023 21:07 collapse

It’s really not cool, man.

Tattorack@lemmy.world on 03 Dec 2023 21:51 collapse

I don’t see why not. Or is this an animal rights thing?

BellaDonna@mujico.org on 03 Dec 2023 21:58 collapse

No, they mean that Autism shouldn’t be cured, which is a common Gen Z take because they see all nuerodivergence as positive and innately of value.

BearOfaTime@lemm.ee on 03 Dec 2023 23:21 next collapse

I would happily make my “special neurodivergence” go away with a shot. And mine is trivial compared to autism.

Fuck anyone with the attitude you describe.

finkrat@lemmy.world on 04 Dec 2023 00:47 collapse

Autism isn’t just a condition, that’s the deal, Autism is a heavily different way of thinking. It shapes Autistic behavior and their viewpoint on life. To them, science has been dedicated to focusing on eradicating a component of their existence, one that a lot of them (definitely not all, there are a lot with your opinion, but I would say a majority) have embraced and wouldn’t want changed. Those Autistics are looking for acceptance, not erasure.

With an anti-Autism treatment available, neurotypical parents will just force it on their Autistic kids, deciding their fate for them, but would also open up an “out” for those who want it, so this isn’t a clear cut good-or-bad thing as one may think.

ricdeh@lemmy.world on 04 Dec 2023 20:44 collapse

Technological and medical progress is not something to be halted based on your personal belief. If there is a way to eliminate a disability, it should be taken, both for the sake of the afflicted and for the entirety of society. You don’t have any right to ruin the lives of people that are born broken but can be repaired.

finkrat@lemmy.world on 06 Dec 2023 18:22 collapse

What if the disability was just neurodivergent people trying to make a livelihood in their way with their abilities, but doing so in a neurotypical world where neurotypicals make the rules and tell neurodivergents that they cannot participate because they act in ways that are not socially acceptable or require accomodation to adapt to enforced neurotypical norms?

Maybe we seem broken because we don’t behave the same way, and maybe the disability exists because we’re inconvenient to the neurotypicals running the show to accommodate

Maybe the lives are already being ruined due to societal policy and unwritten rules and a treatment won’t resolve the root cause of a problem that isn’t our fault to begin with.

tl;dr, no, you change

Tattorack@lemmy.world on 03 Dec 2023 23:26 next collapse

Oh that…

Yeah, I’ve seen that take before. Usually done by people who consider themselves “allies” or have a very mild and none disruptive autism.

flamingo_pinyata@sopuli.xyz on 03 Dec 2023 23:28 collapse

Blame DSM-5 for making the definition of autistic spectrum so broad as to be meaningless.
Tiktokers ran with it and basically defined every exaggerated personality trait as "autism’. Now everyone is autistic.

finkrat@lemmy.world on 04 Dec 2023 00:41 collapse

Yes, I’m sure medical professionals the world over are gauging their assessment criteria on TikTok /s

AllNewTypeFace@leminal.space on 03 Dec 2023 19:19 next collapse

You know those vast cities in China full of brand-new, empty buildings that keep showing up in the news? They’re empty because China doesn’t have enough neurotypical people who could master the sales skills to fill them. This drug is a last-ditch attempt to fill that gap, at the potential expense of sacrificing some engineering capacity.

A_A@lemmy.world on 03 Dec 2023 19:31 next collapse

I like your ideas since it’s the type I need for my writing of fantasy stories. I have quite many wild ideas myself and try to push them to the limit. But, in this area, it’s hard to fend off the disbelief of the reader.

LavaPlanet@lemmy.world on 03 Dec 2023 21:12 collapse

Or fend off the ablism of trying to eradicate autism, instead of just forming a more inclusive world.

A_A@lemmy.world on 03 Dec 2023 22:31 collapse

ableism : Discrimination against persons with disabilities or in favour of those without.

Hum, right, I get what you are saying here.
I believe it’s a gray area. And it is hard to draw the line of what’s a disease and what’s diversity.
For instance, we heard the same speech from deaf people not wanting their deaf kids to wear cochlear thingnies. I say it’s for the kids to make the choice.

Perhyte@lemmy.world on 04 Dec 2023 18:41 collapse

If a deaf person decides to get an implant, or their (hearing?) parents decide for them, and later decides they no longer want it then it’s pretty much reversible, right? They can just not turn it on, or perhaps even have it removed again?

This article is talking about gene therapy, not an assistive device. It’s probably a much more permanent decision.

A_A@lemmy.world on 04 Dec 2023 21:39 collapse

I want to believe !
This new thing “gene therapy” has nice potential …of course there will be (also) extremely bad cases, but overall I decide stubbornly to believe that the positive will outweigh the negative.

Please down-vote my comment here since I am not trying to see your point (which is a fair point by the way 👍).

Korkki@lemmy.world on 03 Dec 2023 20:03 next collapse

wtf is this comment 😅

Skullgrid@lemmy.world on 03 Dec 2023 20:28 collapse

it’s a good joke.

[deleted] on 04 Dec 2023 00:50 collapse

.

RobotToaster@mander.xyz on 03 Dec 2023 19:36 next collapse

when tested on mice

How do they know if a mouse is autistic?

I didn’t even know mice could be autistic.

SCB@lemmy.world on 03 Dec 2023 20:22 next collapse

You just look for the mice that are really into trains.

Blaster_M@lemmy.world on 03 Dec 2023 20:26 next collapse

or dinosaurs

ultra@feddit.ro on 03 Dec 2023 20:50 collapse

My Trains by Lemon Demon starts playing

finkrat@lemmy.world on 04 Dec 2023 00:39 collapse

Lots of animals can. I think they discovered dogs and cats can be in the 60’s or something?

onlinepersona@programming.dev on 03 Dec 2023 22:53 next collapse

If I’m not mistaken, this can already be detected before birth and the woman can have an abortion?

rosymind@leminal.space on 06 Dec 2023 02:32 collapse

You’re thinking of downsyndrome, trisomy …somenumber. You can test for chromosomal abnormalities, but people with autism are often genetically normal. Just like someone with ADHD.

onlinepersona@programming.dev on 06 Dec 2023 18:28 collapse

You’re right. Thanks for the correction.

rosymind@leminal.space on 06 Dec 2023 19:21 collapse

You’re welcome. Now I should correct myself, and say “chomasomally” normal because that’s what those tests look for

Ranvier@sopuli.xyz on 04 Dec 2023 00:08 next collapse

The headline is so hyperbolic it’s basically a lie. It becomes a little tricky because autism spectrum disorder is kind of a broad category. There are certain diseases that have clear genetic causes, other features to their phenotype besides just autism like features, but may share some aspects of autism spectrum disorder symptoms. So often these get lumped in with autism and patients with those disorders also get a diagnosis of autism spectrum disorder. For instance people with fragile x syndrome commonly get an autism diagnosis, but there’s many other features to it as well.

This article stub if following a link at the end is referencing a gene called shank3. It’s not involved in most people classified as having autism spectrum disorder. Mutations in shank3 causes a distinct disorder called Phelan-McDermid syndrome that causes severe intellectual disability, dysmorphic features, autism like features, motor issues, and abnormalities across multiple body systems. Shank3 mutations have also been linked with some cases of schizophrenia. A small minority of people with a diagnosis of autism spectrum disorder have shank3 mutations that may be responsible or pre disposing. So they are testing a gene therapy in mice engineered to have shank3 mutations. Which in humans can have a broad array of phenotypes depending on the mutation, many devastating and severe, some phenotypes of which include autism like features. This will not be very applicable to the vast majority of people classified as having an autism spectrum disorder.

wahming@monyet.cc on 06 Dec 2023 03:36 collapse

So essentially, similar to cancer cures that cure one specific type of cancer but not the rest. I suppose it’s still progress, one step at a time

Mango@lemmy.world on 05 Dec 2023 04:55 next collapse

X

Wahots@pawb.social on 05 Dec 2023 06:13 collapse

Heads up, South China Morning post is an unreliable source for news.